Polymer scaffolds facilitate spinal cord injury repair

Q Zhang, B Shi, J Ding, L Yan, JP Thawani, C Fu… - Acta biomaterialia, 2019 - Elsevier
During the past decades, improving patient neurological recovery following spinal cord
injury (SCI) has remained a challenge. An effective treatment for SCI would not only reduce …

Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery

SM Willerth, SE Sakiyama-Elbert - StemJournal, 2019 - content.iospress.com
Combining stem cells with biomaterial scaffolds serves as a promising strategy for
engineering tissues for both in vitro and in vivo applications. This updated review details …

3D bioprinting pluripotent stem cell derived neural tissues using a novel fibrin bioink containing drug releasing microspheres

R Sharma, IPM Smits, L De La Vega, C Lee… - … in bioengineering and …, 2020 - frontiersin.org
3D bioprinting combines cells with a supportive bioink to fabricate multiscale, multi-cellular
structures that imitate native tissues. Here, we demonstrate how our novel fibrin-based …

Bioprinting a novel glioblastoma tumor model using a fibrin-based bioink for drug screening

C Lee, E Abelseth, L De La Vega, SM Willerth - Materials Today Chemistry, 2019 - Elsevier
Glioblastoma multiforme (GBM), a deadly primary brain cancer, exhibits invasive
proliferation into healthy brain tissue. Currently, novel treatment methods are being …

Direct reprogramming of glioblastoma cells into neurons using small molecules

C Lee, M Robinson, SM Willerth - ACS chemical neuroscience, 2018 - ACS Publications
Glioblastoma multiforme, a type of deadly brain cancer, originates most commonly from
astrocytes found in the brain. Current multimodal treatments for glioblastoma minimally …

Neural stem cell plasticity: advantages in therapy for the injured central nervous system

L Ottoboni, A Merlini, G Martino - Frontiers in cell and developmental …, 2017 - frontiersin.org
The physiological and pathological properties of the neural germinal stem cell niche have
been well-studied in the past 30 years, mainly in animals and within given limits in humans …

Engineering cell aggregates through incorporated polymeric microparticles

CC Ahrens, Z Dong, W Li - Acta Biomaterialia, 2017 - Elsevier
Ex vivo cell aggregates must overcome significant limitations in the transport of nutrients,
drugs, and signaling proteins compared to vascularized native tissue. Further, engineered …

A 3D bioprinted hydrogel mesh loaded with all-trans retinoic acid for treatment of glioblastoma

B Mirani, E Pagan, S Shojaei, J Duchscherer… - European journal of …, 2019 - Elsevier
Abstract Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still
remains a major challenge despite the various therapeutic approaches developed over the …

Fibrin hydrogels induce mixed dorsal/ventral spinal neuron identities during differentiation of human induced pluripotent stem cells

JM Edgar, M Robinson, SM Willerth - Acta Biomaterialia, 2017 - Elsevier
We hypothesized that generating spinal motor neurons (sMNs) from human induced
pluripotent stem cell (hiPSC)-derived neural aggregates (NAs) using a chemically-defined …

3D bioprinting human‐induced pluripotent stem cells and drug‐releasing microspheres to produce responsive neural tissues

L De la Vega, L Abelseth, R Sharma… - Advanced …, 2021 - Wiley Online Library
3D bioprinting can produce complex human tissue mimics using stem cells (SCs). Herein,
cylindrical constructs containing human‐induced pluripotent stem cell (hiPSC)‐derived …