The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Abstract siRNA‐mediated management of myocardial ischemia reperfusion (IR) injury is
greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection …

With the recent FDA approval of the first siRNA‐derived therapeutic, RNA interference
(RNAi)‐mediated gene therapy is undergoing a transition from research to the clinical …

Nanoparticle‐based small interfering RNA (siRNA) therapy shows great promise for
glioblastoma (GBM). However, charge associated toxicity and limited blood–brain‐barrier …

Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in
older populations and is expected to be the most dominant cause of disability in the world …

Nanoparticle-based delivery systems have contributed to the recent clinical success of RNA
therapeutics, including siRNA and mRNA. RNA delivery using polymers has several distinct …

Synthetic structures mimicking the transport function of natural ion channel proteins have a
wide range of applications, including therapeutic treatments, separation membranes …

Cationic polymer vehicles have emerged as promising platforms for nucleic acid delivery
because of their scalability, biocompatibility, and chemical versatility. Advancements in …

Molecular polymer bottlebrushes are densely grafted, individual macromolecules with
nanoscale proportions. The last decade has seen an increased focus on this material class …