Domains of cognition and their assessment

PD Harvey - Dialogues in clinical neuroscience, 2019 - Taylor & Francis
Cognitive performance is typically conceptualized in terms of domains of functioning. These
domains are hierarchical in nature, with the bottom referring to more basic sensory and …

The new genetics of intelligence

R Plomin, S Von Stumm - Nature Reviews Genetics, 2018 - nature.com
Intelligence—the ability to learn, reason and solve problems—is at the forefront of
behavioural genetic research. Intelligence is highly heritable and predicts important …

[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A Okbay, Y Wu, N Wang, H Jayashankar, M Bennett… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

JJ Lee, R Wedow, A Okbay, E Kong, O Maghzian… - Nature …, 2018 - nature.com
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

JE Savage, PR Jansen, S Stringer, K Watanabe… - Nature …, 2018 - nature.com
Intelligence is highly heritable and a major determinant of human health and well-being.
Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

G Davies, M Lam, SE Harris, JW Trampush… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Resource profile and user guide of the Polygenic Index Repository

J Becker, CAP Burik, G Goldman, N Wang… - Nature human …, 2021 - nature.com
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …

Successful memory aging

L Nyberg, S Pudas - Annual review of psychology, 2019 - annualreviews.org
For more than 50 years, psychologists, gerontologists, and, more recently, neuroscientists
have considered the possibility of successful aging. How to define successful aging remains …

Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence

OB Smeland, S Bahrami, O Frei, A Shadrin… - Molecular …, 2020 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …

Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova, G Breen… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body …