Objectives This review examines the pharmacokinetics, modes of action and therapeutic
properties of the anti-malarial drugs, hydroxychloroquine (HCQ) and chloroquine (CQ), in …

Objectives The role of inflammation in OA is controversial and it is unclear whether
suppressing inflammation with conventional or biologic DMARDs is effective. A systematic …

The burden of osteoarthritis (OA) is rapidly increasing with population aging, but there are
still no approved disease-modifying drugs available. Accumulating evidence has shown that …

Objectives: We aimed to evaluate the high-quality literature on the frequency and nature of
major adverse cardiac events (MACE) associated with either hydroxychloroquine (HCQ) or …

Aim Studies have pivoted on the position of microRNAs (miRNAs) in knee osteoarthritis
(KOA) but not the more specific function of miR-199-3p. Thus, this study is to uncover the …

Objective Osteoarthritis (OA) displays features of systemic and local inflammation,
suggesting that DMARDs used in rheumatoid arthritis could potentially also be effective in …

Advances in the understanding of chondrocytes and the synovial membrane as targets of
and participants in the inflammatory process in articular joints have provided insights into the …

Introduction Many concerns still exist regarding the safety of hydroxychloroquine (HCQ) in
the treatment of Coronavirus Disease 2019 (COVID-19). Objectives The purpose of this …

Objective To summarize effects of intravenous bisphosphonates (IVBP) in patients with
symptomatic knee OA and bone marrow lesions (BMLs), using a meta-analysis of …

Background/Aims Conventional disease-modifying anti-rheumatic drugs have been trialed
in osteoarthritis (OA). Hydroxychloroquine (HCQ), which has shown its effectiveness in …