Proteolytic enzymes belonging to the A Disintegin And Metalloproteinase (ADAM) family are
able to cleave transmembrane proteins close to the cell surface, in a process referred to as …

The tumor microenvironment (TME) is composed of multiple infiltrating host cells (eg,
endothelial cells, fibroblasts, lymphocytes, and myeloid cells), extracellular matrix, and …

CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion
and metastasis. Proteolytic cleavage of CD44 plays a critical role in the migration of tumor …

Matrix metalloproteinase (MMPs) and disintegrin and metalloprotease (ADAMs) belong to
the zinc-dependent metalloproteinase family of proteins. These proteins participate in …

Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in
inflammation and cancer. Hyaluronan oligomers are frequently found in these pathological …

Our increasing comprehension of neural crest cell development has reciprocally advanced
our understanding of cadherin expression, regulation, and function. As a transient …

CD44 is a transmembrane cell adhesion molecule that is cleaved by the membrane
proteinase, a disintegrin and metalloproteinase 10 (ADAM10), on the cell surface via …

Osteosarcoma (OS) has become one of the most common primary malignant tumors in the
children and adolescents with a poor prognosis mainly due to high metastasis. A disintegrin …

ADAMs are transmembrane metalloproteases that control cell behavior by cleaving both cell
adhesion and signaling molecules. The cytoplasmic domain of ADAMs can regulate the …

Molting is a widespread developmental process in which the external extracellular matrix
(ECM), the cuticle, is remodeled to allow for organismal growth and environmental …