The management of pain in patients with chronic kidney disease (CKD) is challenging for
many reasons. These patients have increased susceptibility to adverse drug effects due to …

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of
cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid …

Drug-induced kidney injury is a major side effect in clinical practice, frequently leading to
acute renal failure (ARF). It accounts for more than 2% to 15% of cases of ARF in patients …

By inhibiting prostaglandin synthesis, non-steroidal anti-inflammatory drugs (NSAIDs) cause
mucosal damage, ulceration and ulcer complication throughout the gastrointestinal tract …

Activation of the immune system by ANG II contributes to the pathogenesis of hypertension,
and pharmacological suppression of lymphocyte responses can ameliorate hypertensive …

Gambaro G, Perazella MA (Division of Nephrology, University Hospital, Padua, Italy; and
Section of Nephrology, Yale University, New Haven, CT, USA). Adverse renal effects of anti …

Medications cause renal failure through a variety of mechanisms. Hemodynamic renal
failure may result from drugs that reduce renal prostaglandins and hence renal blood flow …

The protean properties of 20-hydroxyeicosatetraenoic acid (HETE), vasoactivity,
mitogenicity, and modulation of transport in key nephron segments, serve as the basis for …

DISCUSSION Selective COX-2 inhibitors were developed to provide analgesia and anti-
inflammatory effects while reducing the gastrointestinal toxicity associated with nonselective …

It is now established that prostanoids play important roles in many cellular responses and
pathophysiologic processes including modulation of the inflammatory reaction, erosion of …