Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Glutamate is the most important excitatory neurotransmitter of the mammalian central
nervous system (CNS), playing an important role in memory, synaptic plasticity and neuronal …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

The prevalence, presentation, and progression of Alzheimer's disease (AD) differ between
men and women, although β-amyloid (Aβ) deposition is a pathological hallmark of AD in …

The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …

Amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release is proposed to be a
crucial early event leading to synapse dysfunction in Alzheimer's disease (AD). In the …

Abstract Phosphoinositide-specific phospholipase Cs (PLCs) are expressed in all
mammalian cells and play critical roles in signal transduction. To obtain a comprehensive …