The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …

C-type natriuretic peptide (CNP) is an autocrine and paracrine mediator released by
endothelial cells, cardiomyocytes and fibroblasts that regulates vital physiological functions …

Atrial fibrillation (AF) is the most common form of sustained clinical arrhythmia. We
previously mapped an AF locus to chromosome 5p13 in an AF family with sudden death in …

The natriuretic peptides (NP) are a family of three polypeptide hormones termed atrial
natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide …

Natriuretic peptides (NPs), including atrial, brain and C‐type natriuretic peptides (ANP, BNP
and CNP), bind two classes of cell surface receptors: the guanylyl cyclase‐linked A and B …

Aims C-type natriuretic peptide (CNP) is an essential endothelium-derived signalling
species that governs vascular homoeostasis; CNP is also expressed in the heart but an …

Natriuretic peptides play a fundamental role in cardiovascular homeostasis by modulation of
fluid and electrolyte balance and vascular tone. C-type natriuretic peptide (CNP) represents …

Thermogenesis and adipogenesis are tightly regulated mechanisms that maintain lipid
homeostasis and energy balance; dysfunction of these critical processes underpins obesity …

The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm
and rate under physiological conditions. Compared to working myocardial cells, pacemaker …

The sympathetic nervous system increases heart rate by activating β adrenergic receptors
and increasing cAMP levels in myocytes in the sinoatrial node. The molecular basis for this …