Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Asthenozoospermia is a common cause of male infertility, but its etiology remains
incompletely understood. We recruited three Pakistani infertile brothers, born to first-cousin …

Purpose Fanconi anemia (FA) genes play important roles in spermatogenesis. In mice,
disruption of Fancm impairs male fertility and testicular integrity, but whether FANCM …

The gap junction protein connexin43 (CX43) plays a vital role in mammalian
spermatogenesis by allowing for direct cytoplasmic communication between neighbouring …

Cadherins are a group of membrane proteins responsible for cell adhesion. They are crucial
for cell sorting and recognition during the morphogenesis, but they also play many other …

The mammalian sex chromosomes have undergone profound changes during their
evolution from an ancestral pair of autosomes [1–4]. Specifically, the X chromosome has …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes COVID-19
infections penetrates body cells by binding to angiotensin-converting enzyme-2 (ACE2) …

STUDY QUESTION Can whole-exome sequencing (WES) reveal pathogenic mutations in
two consanguineous Pakistani families with infertile patients? SUMMARY ANSWER A …

Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …