Mechanisms of multidrug resistance in cancer chemotherapy
K Bukowski, M Kciuk, R Kontek - International journal of molecular …, 2020 - mdpi.com
Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …
methods of cancer healing during the past decades, chemotherapy still remains the main …
Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters
Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …
P-glycoprotein: New insights into structure, physiological function, regulation and alterations in disease
The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …
industry. This resistance is a common occurrence in several diseases and is mediated by …
Natural products from cyanobacteria: Focus on beneficial activities
Cyanobacteria are photosynthetic microorganisms that colonize diverse environments
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …
worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their …
Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability
P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …
[HTML][HTML] A review of biological targets and therapeutic approaches in the management of triple-negative breast cancer
Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …
Clinical perspective of FDA approved drugs with P-glycoprotein inhibition activities for potential cancer therapeutics
JI Lai, YJ Tseng, MH Chen, CYF Huang… - Frontiers in …, 2020 - frontiersin.org
P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …
cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response …
Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer
Cancer often develops multidrug resistance (MDR) when cancer cells become resistant to
numerous structurally and functionally different chemotherapeutic agents. MDR is …
numerous structurally and functionally different chemotherapeutic agents. MDR is …
Mechanisms of taxane resistance
SM Maloney, CA Hoover, LV Morejon-Lasso… - Cancers, 2020 - mdpi.com
Simple Summary Drug resistance is prevalent in many types of cancer and decreases
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
patient survival. The taxanes are anti-mitotic chemotherapeutic agents, widely used since …
Perplexing role of P-glycoprotein in tumor microenvironment
K Robinson, V Tiriveedhi - Frontiers in oncology, 2020 - frontiersin.org
Development of multidrug resistance (MDR) still remains a major obstacle to the long-term
success of cancer therapy. P-glycoprotein (P-gp) is a well-identified membrane transporter …
success of cancer therapy. P-glycoprotein (P-gp) is a well-identified membrane transporter …