Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

Large-scale cell death is commonly observed during organismal development and in human
pathologies,,,–. These cell death events extend over great distances to eliminate large …

Emerging cancer cell ferroptosis features the direct depletion of glutathione (GSH) and
resultant chemical inhibition on glutathione peroxidase 4 (GPX4) bioactivity, which …

Caveolae have been linked to many biological functions, but their precise roles are unclear.
Using quantitative whole-cell proteomics of genome-edited cells, we show that the oxidative …

Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …

Ferroptosis is a form of non-apoptotic regulated cell death (RCD) that depends on iron and
is characterized by the accumulation of lipid peroxides to lethal levels. Ferroptosis involves …

Ferroptosis is a nonapoptotic form of cell death characterized by iron‐dependent lipid
peroxidation in membrane phospholipids. Since its identification in 2012, extensive research …

Ferroptosis is an iron− dependent form of regulated cell death. It has attracted more and
more research interests since it was found because of its potential physiological and …