The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities

DB Zoccal, WI Furuya, M Bassi, DSA Colombari… - Frontiers in …, 2014 - frontiersin.org
It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …

Obstructive sleep apnea, oxidative stress and cardiovascular disease: lessons from animal studies

R Dumitrascu, J Heitmann, W Seeger… - Oxidative medicine …, 2013 - Wiley Online Library
Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular (CV)
diseases such as arterial hypertension, heart failure, and stroke. Based on human research …

Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity

DB Zoccal, AE Simms, LGH Bonagamba… - The Journal of …, 2008 - Wiley Online Library
Chronic intermittent hypoxia (CIH) in rats produces changes in the central regulation of
cardiovascular and respiratory systems by unknown mechanisms. We hypothesized that CIH …

Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia

NR Prabhakar, GK Kumar - Respiratory physiology & neurobiology, 2010 - Elsevier
Sleep disordered breathing with recurrent apneas is one of the most frequently encountered
breathing disorder in adult humans and preterm infants. Recurrent apnea patients exhibit …

Increased sympathetic activity in rats submitted to chronic intermittent hypoxia

DB Zoccal, LGH Bonagamba… - Experimental …, 2007 - Wiley Online Library
Long‐term exposure to intermittent hypoxia may lead to important cardiovascular
dysfunctions, such as hypertension. Rodent models of chronic intermittent hypoxia (CIH) …

[HTML][HTML] Peripheral chemoreception and arterial pressure responses to intermittent hypoxia

NR Prabhakar, YJ Peng, GK Kumar… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
Carotid bodies are the principal peripheral chemoreceptors for detecting changes in arterial
blood oxygen levels, and the resulting chemoreflex is a potent regulator of blood pressure …

Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding of the human disease

M Dematteis, D Godin-Ribuot, C Arnaud, C Ribuot… - ILAR …, 2009 - academic.oup.com
Sleep-disordered breathing, and particularly the highly prevalent obstructive sleep apnea
syndrome, is a multicomponent disorder combining intermittent hypoxia (IH), sleep …

Sympatho-adrenal activation by chronic intermittent hypoxia

NR Prabhakar, GK Kumar… - Journal of Applied …, 2012 - journals.physiology.org
Recurrent apnea with chronic intermittent hypoxia (CIH) is a major clinical problem in adult
humans and infants born preterm. Patients with recurrent apnea exhibit heightened …

The cardiovascular and metabolic effects of chronic hypoxia in animal models: a mini-review

LA Barnes, OA Mesarwi, A Sanchez-Azofra - Frontiers in physiology, 2022 - frontiersin.org
Animal models are useful to understand the myriad physiological effects of hypoxia. Such
models attempt to recapitulate the hypoxemia of human disease in various ways. In this mini …

Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia

AQ Silva, AM Schreihofer - The Journal of physiology, 2011 - Wiley Online Library
Non‐technical summary Exposure to chronic intermittent hypoxia (CIH) leads to chronically
elevated sympathetic nerve activity (SNA) and mean arterial pressure (MAP) with …