Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

Estrogen receptors are expressed and their cognate ligands produced in all vertebrates,
indicative of important and conserved functions. Through evolution estrogen has been …

В доступной форме в книге изложены основные события, произошедшие в
медицинской генетике и в молекулярной медицине после расшифровки генома …

Osteoporosis (OMIM166710) is a common skeletal disorder characterized by low bone mass
and microarchitectural deterioration of bone tissue with increased susceptibility to fracture …

ContextBoth bone mineral density (BMD) and fracture risk have a strong genetic component.
Estrogen receptor α (ESR1) is a candidate gene for osteoporosis, but previous studies of …

Context Estrogen and related hormone therapies activate estrogen receptors, which in turn
regulate genes for several cardiovascular disease (CVD) risk factors. Relatively little is …

Osteoporosis is a common disease with a strong genetic component. Twin studies have
shown that genetic factors play an important role in regulating bone mineral density (BMD) …

ContextThe role of estrogens in ischemic heart disease (IHD) is uncertain. Evidence
suggests that genetic variations in the estrogen receptor α (ESR1) gene may influence IHD …

The contribution of genetic polymorphisms to bone mineral density (BMD) and fracture risk
in women is a controversial topic. We evaluated the effect of the Xba I and Pvu II …

Estrogen receptor alpha (ERα, NR3A1) contributes through its expression in different tissues
to a spectrum of physiological processes, including reproductive system development and …