Electronic health records and polygenic risk scores for predicting disease risk

R Li, Y Chen, MD Ritchie, JH Moore - Nature Reviews Genetics, 2020 - nature.com
Accurate prediction of disease risk based on the genetic make-up of an individual is
essential for effective prevention and personalized treatment. Nevertheless, to date …

The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential …

LJ Beesley, M Salvatore, LG Fritsche… - Statistics in …, 2020 - Wiley Online Library
Biobanks linked to electronic health records provide rich resources for health‐related
research. With improvements in administrative and informatics infrastructure, the availability …

Does biologic therapy impact the development of PsA among patients with psoriasis?

E Meer, JF Merola, R Fitzsimmons, TJ Love… - Annals of the …, 2022 - ard.bmj.com
Objective To examine the association of biologic therapy use for psoriasis with incident
psoriatic arthritis (PsA) diagnosis. Methods A retrospective cohort study was conducted in …

Use of deep learning to analyze social media discussions about the human papillomavirus vaccine

J Du, C Luo, R Shegog, J Bian… - JAMA network …, 2020 - jamanetwork.com
Importance Human papillomavirus (HPV) vaccine hesitancy or refusal is common among
parents of adolescents. An understanding of public perceptions from the perspective of …

Replication of real-world evidence in oncology using electronic health record data extracted by machine learning

CM Benedum, A Sondhi, E Fidyk, AB Cohen, S Nemeth… - Cancers, 2023 - mdpi.com
Simple Summary Obtaining and structuring information about the characteristics, treatments,
and outcomes of people living with cancer for research purposes is difficult and resource …

A framework for understanding selection bias in real-world healthcare data

R Kundu, X Shi, J Morrison, J Barrett… - Journal of the Royal …, 2024 - academic.oup.com
Using administrative patient-care data such as Electronic Health Records (EHR) and
medical/pharmaceutical claims for population-based scientific research has become …

An augmented estimation procedure for EHR-based association studies accounting for differential misclassification

J Tong, J Huang, J Chubak, X Wang… - Journal of the …, 2020 - academic.oup.com
Objectives The ability to identify novel risk factors for health outcomes is a key strength of
electronic health record (EHR)-based research. However, the validity of such studies is …

[HTML][HTML] Guidance of development, validation, and evaluation of algorithms for populating health status in observational studies of routinely collected data (DEVELOP …

W Wang, YH Jin, M Liu, Q He… - Military Medical …, 2024 - mmrjournal.biomedcentral.com
In recent years, there has been a growing trend in the utilization of observational studies that
make use of routinely collected healthcare data (RCD). These studies rely on algorithms to …

Five analytic challenges in working with electronic health records data to support clinical trials with some solutions

BA Goldstein - Clinical Trials, 2020 - journals.sagepub.com
Electronic health records data are becoming a key data resource in clinical research. Owing
to issues of data efficiency, electronic health records data are being used for clinical trials …

A cost-effective chart review sampling design to account for phenotyping error in electronic health records (EHR) data

Z Yin, J Tong, Y Chen, RA Hubbard… - Journal of the American …, 2022 - academic.oup.com
Objectives Electronic health records (EHR) are commonly used for the identification of novel
risk factors for disease, often referred to as an association study. A major challenge to EHR …