Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …

Conus regius is a marine venomous mollusk of the Conus genus that captures its prey by
injecting a rich cocktail of bioactive disulfide bond rich peptides called conotoxins. These …

In the nervous system, nicotinic acetylcholine receptors (nAChRs) rapidly transduce a
chemical signal into one that is electrical via ligand-gated ion flux through the central …

Introduction Hearing loss is a major health problem, impacting education, communication,
interpersonal relationships, and mental health. Drugs that prevent or restore hearing are …

In the pressing quest of novel treatments for chronic pain, α7 nAChR silent agonists show
efficacy as anti-inflammatory modulators and represent a promising strategy. Recent …

Although α2 was the first neuronal nicotinic acetylcholine receptor (nAChR) receptor subunit
to be cloned, due to its low level of expression in rodent brain, its study has largely been …

After the transition to life on land, tympanic middle ears emerged separately in different
groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way …

The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-
permeable ion channel that mediates synaptic transmission between descending efferent …

In the developing cochlea, just before the onset of hearing on postnatal day 12, the medial
olivocochlear efferent axons in synaptic contact with the inner hair cells (IHCs) start …