[HTML][HTML] Retinal stem cell transplantation: Balancing safety and potential

MS Singh, SS Park, TA Albini, MV Canto-Soler… - Progress in retinal and …, 2020 - Elsevier
Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

[PDF][PDF] Biomaterials to enhance stem cell transplantation

BN Kharbikar, P Mohindra, TA Desai - Cell Stem Cell, 2022 - cell.com
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

R Sharma, V Khristov, A Rising, BS Jha… - Science translational …, 2019 - science.org
Considerable progress has been made in testing stem cell–derived retinal pigment
epithelium (RPE) as a potential therapy for age-related macular degeneration (AMD) …

[PDF][PDF] Regenerating eye tissues to preserve and restore vision

JH Stern, Y Tian, J Funderburgh, G Pellegrini, K Zhang… - Cell stem cell, 2018 - cell.com
Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding
disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age …

Stem cell based therapies for age-related macular degeneration: the promises and the challenges

H Nazari, L Zhang, D Zhu, GJ Chader… - Progress in retinal and …, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

The future of regenerative medicine: cell therapy using pluripotent stem cells and acellular therapies based on extracellular vesicles

M Jarrige, E Frank, E Herardot, S Martineau, A Darle… - Cells, 2021 - mdpi.com
The rapid progress in the field of stem cell research has laid strong foundations for their use
in regenerative medicine applications of injured or diseased tissues. Growing evidences …

Subretinal injection: a review on the novel route of therapeutic delivery for vitreoretinal diseases

Y Peng, L Tang, Y Zhou - Ophthalmic research, 2017 - karger.com
Compared to intravitreal injection, subretinal injection has more direct effects on the
targeting cells in the subretinal space, which provides a new therapeutic method for …

Cell-based therapy for degenerative retinal disease

M Zarbin - Trends in molecular medicine, 2016 - cell.com
Stem cell-derived retinal pigment epithelium (RPE) and photoreceptors (PRs) have restored
vision in preclinical models of human retinal degenerative disease. This review discusses …

[HTML][HTML] Moving stem cells to the clinic: potential and limitations for brain repair

JA Steinbeck, L Studer - Neuron, 2015 - cell.com
Stem cell-based therapies hold considerable promise for many currently devastating
neurological disorders. Substantial progress has been made in the derivation of disease …

Let there be light: gene and cell therapy for blindness

D Dalkara, O Goureau, K Marazova… - Human gene therapy, 2016 - liebertpub.com
Retinal degenerative diseases are a leading cause of irreversible blindness. Retinal cell
death is the main cause of vision loss in genetic disorders such as retinitis pigmentosa …