Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches

NI Bohnen, AJ Yarnall, RS Weil, E Moro… - The Lancet …, 2022 - thelancet.com
In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …

Targeted vagus nerve stimulation for rehabilitation after stroke

ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …

[HTML][HTML] Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

S Bowles, J Hickman, X Peng, WR Williamson… - Neuron, 2022 - cell.com
Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation

DR Hulsey, JR Riley, KW Loerwald… - Experimental …, 2017 - Elsevier
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …

Vagus nerve stimulation enhances stable plasticity and generalization of stroke recovery

EC Meyers, BR Solorzano, J James, PD Ganzer… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Chronic impairment of the arm and hand is a common
consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve …

Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury

PG Nagappan, H Chen, DY Wang - Military Medical Research, 2020 - Springer
Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Vagus nerve stimulation and the cardiovascular system

MJ Capilupi, SM Kerath… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The vagus nerve plays an important role in maintaining physiological homeostasis, which
includes reflex pathways that regulate cardiac function. The link between vagus nerve …

Advanced neurotechnologies for the restoration of motor function

S Micera, M Caleo, C Chisari, FC Hummel, A Pedrocchi - Neuron, 2020 - cell.com
Stroke is one of the leading causes of long-term disability. Advanced technological solutions
(" neurotechnologies") exploiting robotic systems and electrodes that stimulate the nervous …

Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

PD Ganzer, MJ Darrow, EC Meyers, BR Solorzano… - Elife, 2018 - elifesciences.org
Recovery from serious neurological injury requires substantial rewiring of neural circuits.
Precisely-timed electrical stimulation could be used to restore corrective feedback …