Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …

The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal
cord, providing sensory input to the micturition centers within the central nervous system …

Background & Aims Proper colon function requires signals from extrinsic primary afferent
neurons (ExPANs) located in spinal ganglia. Most ExPANs express the vanilloid receptor …

Pain associated with skeletal pathology or disease is a significant clinical problem, but the
mechanisms that generate and/or maintain it remain poorly understood. In this study, we …

Simple Summary Tumor immune evasion is one of the hallmarks of tumor progression that
enables tumor growth despite the activity of the host immune system. It is mediated by …

The neurotrophic factors are well known for their implication in the growth and the survival of
the central, sensory, enteric and parasympathetic nervous systems. Due to these properties …

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder
disorder with limited therapeutic options currently available. The present review provides an …

In the peripheral nervous system, ligand-receptor interactions between cells and neurons
shape sensory experience, including pain. We set out to identify the potential interactions …

Tissue injury prompts the release of a number of proalgesic molecules that induce acute and
chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical …

Osteoarthritis (OA) associated pain (OA-pain) is a significant global problem. OA-pain limits
limb use and mobility and is associated with widespread sensitivity. Therapeutic options are …