Dextromethorphan (DM) has been used for more than 50 years as an over-the-counter
antitussive. Studies have revealed a complex pharmacology of DM with mechanisms …

A substantial amount of research has shown that N-methyl-D-aspartate receptors (NMDARs)
may play a key role in the pathophysiology of several neurological diseases, including …

Dextromethorphan (DM) is a commonly used antitussive and is currently the only FDA-
approved pharmaceutical treatment for pseudobulbar affect. Its safety profile and diverse …

N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous
system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and …

Over the last decade, sigma-1 receptor (Sig1R) has been recognized as a valid target for the
treatment of seizure disorders and seizure-related comorbidities. Clinical trials with Sig1R …

Introduction: Agitation is common and distressing in patients with Alzheimer-type dementia,
but safe, effective treatments remain elusive. Psychological treatments are first-line options …

Background: Dextromethorphan (DM) is a widely-used antitussive. DM's complex central
nervous system (CNS) pharmacology became of interest when it was discovered to be …

Cough is a defense mechanism that prevents the entry of noxious materials into the
respiratory system and clears foreign materials and excess secretions from the lungs and …

Status epilepticus (SE) is a neurological emergency with a high mortality rate. When
compared to chronic epilepsy, it is distinguished by the durability of seizures and frequent …

Dextrometrophan (DM), widely used as an antitussive, has recently generated interest as an
anticonvulsant drug. Some effects of dextrometrophan are associated with alterations in …