DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the
DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes …

Genes encoding histone proteins are recurrently mutated in tumor samples, and these
mutations may impact nucleosome stability, histone post-translational modification, or …

Chromatin dysfunction has been implicated in a growing number of cancers especially in
children and young adults. In addition to chromatin-modifying and-remodeling enzymes …

Histone modifications are associated with regulation of gene expression that controls a vast
array of biological processes. Often, these associations are drawn by correlating the …

The involvement of histone modifications in cartilage development, pathology and
regeneration is becoming increasingly evident. Understanding the molecular mechanisms …

Elevated expression of lysine demethylase 6A (KDM6A) and lysine demethylase 6B
(KDM6B) has been reported in prostate cancer (PCa). However, the mechanism underlying …

Histone hypermethylation represses gene transcription, which affects cartilage homeostasis
or joint remodeling. Trimethylation of lysine 27 of histone 3 (H3K27me3) changes …

Epigenetic reprogramming is the leading mechanism for cell differentiation in early
development which gradually takes place upon zygote formation. This is governed by …