Extracellular acid can have important effects on neuron function. In central and peripheral
neurons, acid-sensing ion channels (ASICs) have emerged as key receptors for extracellular …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

Ca 2+ toxicity remains the central focus of ischemic brain injury. The mechanism by which
toxic Ca 2+ loading of cells occurs in the ischemic brain has become less clear as multiple …

Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that
belong to the epithelial sodium channel/degenerin family of ion channels and are implicated …

Acid-sensing ion channels (ASICs) detect extracellular protons produced during
inflammation or ischemic injury and belong to the superfamily of degenerin/epithelial sodium …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …

From a systematic screening of animal venoms, we isolated a new toxin (APETx2) from the
sea anemone Anthopleura elegantissima, which inhibits ASIC3 homomeric channels and …

Acid-sensing ion channel (ASIC) 1a subunit is expressed in synapses of central neurons
where it contributes to synaptic plasticity. However, whether these channels can conduct …

Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …