Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

Macrophage polarization refers to the process by which macrophages can produce two
distinct functional phenotypes: M1 or M2. The balance between both strongly affects the …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Doxorubicin (Dox), an antitumor antibiotic, has therapeutic effects on many kinds of tumors.
However, Dox can produce some serious side effects that limit its clinical application. Thus …

Context Kaempferol, a flavonoid glycoside, has many hepatoprotective effects in several
animals due to its antioxidant potential. Objective This study evaluated the hepatoprotective …

Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced
liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid …

Non-alcoholic fatty liver disease (NAFLD) is a common disease that causes serious liver
damage. Exercise is recognized as a non-pharmacological tool to improve the pathology of …

Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due
to adverse effects on healthy tissues, especially the liver. Therefore, it is necessary to …

Abstract Sirtuins (SIRT1-SIRT7), as a family of NAD+-dependent protein modifying enzymes,
have various catalytic functions, such as deacetylases, dealkalylases, and deribonucleases …