The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20
years have shown that anti-CD3 monoclonal antibodies (mAbs) effectively treat autoimmune …

Oral antigen administration to induce regulatory T cells (Treg) takes advantage of regulatory
mechanisms that the gastrointestinal tract utilizes to promote unresponsiveness against food …

Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

Although the therapeutic armamentarium of Inflammatory bowel diseases (IBD) physicians
has expanded rapidly in recent years, a proportion of patients remain with a suboptimal …

Abstract Psycho-Neuro-Endocrine-Immunology (PNEI) is a scientific field of study that
investigates the link between bidirectional communications among the nervous system, the …

The immune system plays a role in the pathogenesis of non-alcoholic steatohepatitis
(NASH) underlying hepatocyte injury and fibrosis progression at all disease stages. Oral …

Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are
chronic relapsing inflammatory gastrointestinal tract diseases of uncertain origin, which are …

Active tolerance to ingested dietary antigens forms the basis for oral immunotherapy to food
allergens or autoimmune self-antigens. Alternatively, oral administration of anti-CD3 …

Background Parenteral anti-CD3 Mab (OKT3) has been used to treat transplant rejection
and parental administration of a humanized anti-CD3 Mab (Teplizumab) showed positive …

Inflammatory bowel diseases (IBD) are associated with an altered systemic immune
response leading to inflammation‐mediated damage to the gut and other organs. Oral …