Nanomaterials as drug delivery agents for overcoming the blood-brain barrier: A
comprehensive review Skoči na glavni sadržaj english Prijava i registracija Prijava …

The 21st‐century toxicity testing program recommends the use of cytotoxicity data from
human cells in culture for rapid in vitro screening focusing on biological pathways of …

Cell-based metabolomics provides multiparametric physiologically relevant readouts that
can be highly advantageous for improved, biologically based decision making in early …

Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to
clinical trial failures and market withdrawals due to liver toxicity. This study presents …

Abstract Background Primary human hepatocytes (PHHs) are highly valuable for drug-
metabolism evaluation, liver disease modeling and hepatocyte transplantation. However …

The urgent need for effective treatments against emerging viral diseases, driven by drug-
resistant strains and new viral variants, remains critical. We focus on inhibiting the human …

Animal experiments are often required for biological studies. However, in vitro cell culture
models, such as cell-culture inserts and microphysiological systems, can provide a suitable …

Natural resources including plants provide a rich supply of new drugs (Newman and Cragg,
2020). Many plants have been used in folk medicine to alleviate the symptoms of various …

Reactive metabolite (RM) formation is widely accepted as playing a pivotal role in causing
adverse idiosyncratic drug reactions, with most attention paid to drug-induced liver injury …

Toxicology, the study of the adverse effects of chemicals and physical agents on living
organisms, is a critical process in chemical and drug development. The low throughput, high …