Modified polynucleotides for reducing off-target effects in RNA interference
D Leake, A Reynolds, A Khvorova, W Marshall… - US Patent …, 2009 - Google Patents
Methods and compositions for performing RNA interference with decreased off-target effects
are provided The methods and compositions permit effective and efficient applications of …
are provided The methods and compositions permit effective and efficient applications of …
Oligoribonucleotides and ribonucleases for cleaving RNA
ST Crooke - US Patent 7,695,902, 2010 - Google Patents
Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
C Allerson, B Bhat, AB Eldrup, M Manoharan… - US Patent …, 2013 - Google Patents
2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
Positionally modified siRNA constructs
B Bhat, EE Swayze, TP Prakash, C Allerson… - US Patent …, 2013 - Google Patents
The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …
Modified RNAi polynucleotides and uses thereof
The invention relates to improved RNAi constructs and uses thereof. The construct has a
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2018 - Google Patents
2013-06-19 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2014 - Google Patents
2013-01-11 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2015 - Google Patents
The present invention relates to RNAi constructs with minimal double-stranded regions, and
their use in gene silencing. RNAi constructs associated with the invention include a double …
their use in gene silencing. RNAi constructs associated with the invention include a double …
Reduced size self-delivering RNAi compounds
A Khvorova, W Salomon, J Kamens… - US Patent …, 2015 - Google Patents
2013-06-17 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …
2′-substituted oligomeric compounds and compositions for use in gene modulations
BF Baker, AB Eldrup, M Manoharan, B Bhat… - US Patent …, 2011 - Google Patents
5.77. 19s. A 1, 1993 Sieve et al.............. 514/45 Sugar and/or backbone modification. In some
embodiments 5,214.34 A 5, 1993 Weis et al....... 536, 25.3 the modification is a 2. Substituent …
embodiments 5,214.34 A 5, 1993 Weis et al....... 536, 25.3 the modification is a 2. Substituent …