[HTML][HTML] Early life adversities, psychopathologies and novel pharmacological strategies

A Cattaneo, V Begni, V Zonca, MA Riva - Pharmacology & Therapeutics, 2024 - Elsevier
Exposure to adversities during early life stages (early life adversities-ELA), ranging from
pregnancy to adolescence, represents a major risk factor for the vulnerability to mental …

Pubertal maternal presence reduces anxiety and increases adult neurogenesis in Kunming mice offspring

P Yu, M Cheng, N Wang, C Wu, K Qiang - Pharmacology Biochemistry and …, 2024 - Elsevier
Puberty is a critical period of emotional development and neuroplasticity. However, most
studies have focused on early development, with limited research on puberty, particularly …

Lasting effects of adolescent social instability stress on dendritic morphology in the nucleus accumbens in female and male Long Evans rats

A Patel, A Aljaabary, YJ Yuan, P Asgari… - Neurotoxicology and …, 2024 - Elsevier
Social instability stress (SS) in adolescence in rats leads to long-lasting changes in social
behaviour and reward-related behaviour relative to control rats. Given the role of the nucleus …

Social context as a source of variability in the psychological sciences

LA Agee, A Fourtassi, MH Monfils - Frontiers in Human Neuroscience, 2025 - frontiersin.org
Poor reproducibility in the psychological sciences is often attributed to systemic factors such
as publication bias and lack of financial support sources for replication studies (Open …

A Behavioral Screening Method for Predicting PTSD-like Phenotypes: Novel Application to Female Rats

G Chiacchierini, GF Mancini, B Di Cesare… - Journal of Neuroscience …, 2025 - Elsevier
Background Only a small percentage of trauma-exposed subjects develop PTSD, with
females being twice as likely. Most rodent models focus on males and fail to account for inter …

Sexual differentiation of neural mechanisms of stress sensitivity during puberty

EC Wright, PX Luo, HC Zakharenkov… - Proceedings of the …, 2023 - National Acad Sciences
Anxiety disorders are a major public health concern and current treatments are inadequate
for many individuals. Anxiety is more common in women than men and this difference arises …

Synaptic pruning during adolescence shapes adult social behavior in both males and females

JM Kirkland, EL Edgar, I Patel, P Feustel… - Developmental …, 2024 - Wiley Online Library
Evolutionarily conserved, peer‐directed social behaviors are essential to participate in many
aspects of human society. These behaviors directly impact psychological, physiological, and …

[HTML][HTML] Adolescent development of anxiety-related behavior and shifts in behavioral responsiveness to estradiol in female mice

KM Schulz, MC Chavez, Z Forrester-Fronstin - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Early pubertal onset during adolescence is consistently linked with increased risk of anxiety
and depression in girls. Although estradiol tends to have anxiolytic effects in adulthood …

Prefrontal cortex proteomic alteration after social instability stress in adolescents rats

ECS Santos, AF Terceiro, R Vitorino, I Lopes, RL Alves… - bioRxiv, 2023 - biorxiv.org
Early life stress can have significant effects on the developing brain and lead to changes in
the structure and function of brain regions involved in stress regulation, emotion and …

Behavioral Sex Differences Caused by Distinct Vasopressin Sources

N Rigney - 2023 - scholarworks.gsu.edu
Dysfunction in social communication is a prominent aspect of many psychopathologies and
social disorders including autism, schizophrenia, and social anxiety. Consequently …