New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Lower-risk cannabis use guidelines: a comprehensive update of evidence and recommendations

B Fischer, C Russell, P Sabioni… - … journal of public …, 2017 - ajph.aphapublications.org
Background. Cannabis use is common in North America, especially among young people,
and is associated with a risk of various acute and chronic adverse health outcomes …

Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems

J Moltke, C Hindocha - Journal of cannabis research, 2021 - Springer
Background Public and medical interest in cannabidiol (CBD) has been rising, and CBD is
now available from various sources. Research into the effects of low-dose CBD on outcomes …

Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis

G Hindley, K Beck, F Borgan, CE Ginestet… - The Lancet …, 2020 - thelancet.com
Background Approximately 188 million people use cannabis yearly worldwide, and it has
recently been legalised in 11 US states, Canada, and Uruguay for recreational use. The …

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

O Devinsky, MR Cilio, H Cross, J Fernandez‐Ruiz… - …, 2014 - Wiley Online Library
To present a summary of current scientific evidence about the cannabinoid, cannabidiol
(CBD) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders …

Cannabis, cannabinoids, and health

G Lafaye, L Karila, L Blecha… - Dialogues in clinical …, 2017 - Taylor & Francis
Cannabis (also known as marijuana) is the most frequently used illicit psychoactive
substance in the world. Though it was long considered to be a “soft” drug, studies have …

Are cannabidiol and Δ9‐tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

JM McPartland, M Duncan, V Di Marzo… - British journal of …, 2015 - Wiley Online Library
Based upon evidence that the therapeutic properties of C annabis preparations are not
solely dependent upon the presence of Δ9‐tetrahydrocannabinol (THC), pharmacological …

Cannabidiol (CBD) use in psychiatric disorders: A systematic review

S Bonaccorso, A Ricciardi, C Zangani, S Chiappini… - Neurotoxicology, 2019 - Elsevier
Abstract Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) are the most represented
phytocannabinoids in Cannabis sativa plants. However, CBD may present with a different …

How does cannabidiol (CBD) influence the acute effects of delta-9-tetrahydrocannabinol (THC) in humans? A systematic review

AM Freeman, K Petrilli, R Lees, C Hindocha… - Neuroscience & …, 2019 - Elsevier
The recent liberalisation of cannabis regulation has increased public and scientific debate
about its potential benefits and risks. A key focus has been the extent to which cannabidiol …

[HTML][HTML] Dosage, efficacy and safety of cannabidiol administration in adults: a systematic review of human trials

C Larsen, J Shahinas - Journal of clinical medicine research, 2020 - ncbi.nlm.nih.gov
Considering data from in vitro and in vivo studies, cannabidiol (CBD) seems to be a
promising candidate for the treatment of both somatic and psychiatric disorders. The aim of …