Stem cells and exosomes: new therapies for intervertebral disc degeneration

Z Krut, G Pelled, D Gazit, Z Gazit - Cells, 2021 - mdpi.com
Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic
and catabolic processes in the intervertebral disc, leading to an alteration in the composition …

[HTML][HTML] Regulating pyroptosis by mesenchymal stem cells and extracellular vesicles: A promising strategy to alleviate intervertebral disc degeneration

S Yang, Y Zhang, Q Peng, B Meng, J Wang… - Biomedicine & …, 2024 - Elsevier
Intervertebral disc degeneration (IVDD) is a main cause of low back pain (LBP), which can
lead to disability and thus generate a heavy burden on society. IVDD is characterized by a …

The role of microenvironment in stem cell-based regeneration of intervertebral disc

G Chu, W Zhang, F Han, K Li, C Liu, Q Wei… - … in Bioengineering and …, 2022 - frontiersin.org
Regenerative medicine for intervertebral disc (IVD) disease, by utilizing chondrocytes, IVD
cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has …

Human embryonic stem-cell-derived exosomes repress NLRP3 inflammasome to alleviate pyroptosis in nucleus pulposus cells by transmitting miR-302c

Y Yu, W Li, T Xian, M Tu, H Wu, J Zhang - International Journal of …, 2023 - mdpi.com
Recent studies have shown that the NOD-, LRR-, and pyrin domain-containing protein 3
(NLRP3) inflammasome is extensively activated in the process of intervertebral disc …

[HTML][HTML] Roles of Hippo–YAP/TAZ signalling in intervertebral disc degeneration

S Zheng-Wei, T Yuan, F Chao-Shuai, Z Lei… - Biomedicine & …, 2023 - Elsevier
Intervertebral disc degeneration (IVDD), a common cartilage-degenerative disease, is
considered the main cause of low back pain (LBP). Owing to the complex aetiology and …

Intervertebral disc stem/progenitor cells: a promising “Seed” for intervertebral disc regeneration

Y Du, Z Wang, Y Wu, C Liu, L Zhang - Stem Cells International, 2021 - Wiley Online Library
Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back
pain (LBP), which has become more prevalent from 21 century, causing an enormous …

Revolutionizing Intervertebral Disc Regeneration: Advances and Future Directions in Three-Dimensional Bioprinting of Hydrogel Scaffolds

X Zhang, X Gao, X Zhang, X Yao… - International Journal of …, 2024 - Taylor & Francis
Hydrogels are multifunctional platforms. Through reasonable structure and function design,
they use material engineering to adjust their physical and chemical properties, such as pore …

Cartilage Endplate-Derived Stem Cells for Regeneration of Intervertebral Disc Degeneration: An Analytic Study

Z Jia, D Liu, X Li, T Wen, W Li - Journal of Inflammation Research, 2023 - Taylor & Francis
Purpose Intervertebral disc degeneration (IDD) is considered the predominant cause of low
back pain (LBP) and accounts for global disability and a substantial socioeconomic burden …

Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration

JY Ding, X Yan, RJ Zhang, HQ Zhang, L Kang… - European Journal of …, 2024 - Springer
Objective Intervertebral disc degeneration (IVDD) is a major cause of morbidity and
disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein …

Exosomes derived from human urine–derived stem cells ameliorate IL-1β-induced intervertebral disk degeneration

G Qian, Y Yu, Y Dong, Y Hong, M Wang - BMC Musculoskeletal Disorders, 2024 - Springer
Background Human intervertebral disk degeneration (IVDD) is a sophisticated degenerative
pathological process. A key cause of IVDD progression is nucleus pulposus cell (NPC) …