Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …

[HTML][HTML] Therapeutic potential of natural compounds acting through epigenetic mechanisms in cardiovascular diseases: Current findings and future directions

P Bontempo, L Capasso, L De Masi, A Nebbioso… - Nutrients, 2024 - mdpi.com
Cardiovascular diseases (CVDs) remain a leading global cause of morbidity and mortality.
These diseases have a multifaceted nature being influenced by a multitude of biochemical …

[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies

X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

[HTML][HTML] Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

S Mascharak, HE Talbott, M Januszyk, M Griffin… - Cell Stem Cell, 2022 - cell.com
Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …

Targeting gut microbiota–derived kynurenine to predict and protect the remodeling of the pressure-overloaded young heart

B Shi, X Zhang, Z Song, Z Dai, K Luo, B Chen… - Science …, 2023 - science.org
Pressure-overloaded left ventricular remodeling in young population is progressive and
readily degenerate into heart failure. The aims of this study were to identify a plasma …

Single-cell transcriptomic atlas of different human cardiac arteries identifies cell types associated with vascular physiology

Z Hu, W Liu, X Hua, X Chen, Y Chang… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Although cellular heterogeneity within arterial walls has been explored in mice
and nonhuman primates, the cellular composition of human arterial walls remains unclear …

Recent advances on the roles of LncRNAs in cardiovascular disease

Y Fang, Y Xu, R Wang, L Hu, D Guo… - Journal of Cellular …, 2020 - Wiley Online Library
Cardiovascular diseases are a main cause of mortality whose prevalence continues to
increase worldwide. Long non‐coding RNAs (lncRNAs) regulate a variety of biological …

[HTML][HTML] Compound AC1Q3QWB upregulates CDKN1A and SOX17 by interrupting the HOTAIR—EZH2 interaction and enhances the efficacy of tazemetostat in …

L Chen, X Zheng, W Liu, Y Sun, S Zhao, L Tian, W Tian… - Cancer Letters, 2023 - Elsevier
Endometrial cancer (EC) is a common malignancy of the female reproductive system, with
an escalating incidence. Recurrent/metastatic EC presents a poor prognosis. The interaction …

MicroRNA-365 regulates human cardiac action potential duration

D Esfandyari, BMG Idrissou, K Hennis… - Nature …, 2022 - nature.com
Abnormalities of ventricular action potential cause malignant cardiac arrhythmias and
sudden cardiac death. Here, we aim to identify microRNAs that regulate the human cardiac …

Nonsteroidal Mineralocorticoid receptor antagonism by finerenone—translational aspects and clinical perspectives across multiple organ systems

P Kolkhof, R Lawatscheck, G Filippatos… - International journal of …, 2022 - mdpi.com
Perception of the role of the aldosterone/mineralocorticoid receptor (MR) ensemble has
been extended from a previously renal epithelial-centered focus on sodium and volume …