DNA nanotechnology as an emerging tool to study mechanotransduction in living systems

VPY Ma, K Salaita - Small, 2019 - Wiley Online Library
The ease of tailoring DNA nanostructures with sub‐nanometer precision has enabled new
and exciting in vivo applications in the areas of chemical sensing, imaging, and gene …

Dynamic bonds and their roles in mechanosensing

C Zhu, Y Chen, LA Ju - Current opinion in chemical biology, 2019 - Elsevier
Mechanical forces are ubiquitous in a cell's internal structure and external environment.
Mechanosensing is the process that the cell employs to sense its mechanical environment …

Single-molecule characterization of subtype-specific β1 integrin mechanics

MH Jo, J Li, V Jaumouillé, Y Hao, J Coppola… - Nature …, 2022 - nature.com
Although integrins are known to be mechanosensitive and to possess many subtypes that
have distinct physiological roles, single molecule studies of force exertion have thus far …

RAD-TGTs: high-throughput measurement of cellular mechanotype via rupture and delivery of DNA tension probes

MR Pawlak, AT Smiley, MP Ramirez, MD Kelly… - Nature …, 2023 - nature.com
Mechanical forces drive critical cellular processes that are reflected in mechanical
phenotypes, or mechanotypes, of cells and their microenvironment. We present here …

Deep learning for live cell shape detection and automated afm navigation

J Rade, J Zhang, S Sarkar, A Krishnamurthy, J Ren… - Bioengineering, 2022 - mdpi.com
Atomic force microscopy (AFM) provides a platform for high-resolution topographical
imaging and the mechanical characterization of a wide range of samples, including live …

Real-time measurement of molecular tension during cell adhesion and migration using multiplexed differential analysis of tension gauge tethers

MH Jo, WT Cottle, T Ha - ACS Biomaterials Science & Engineering, 2018 - ACS Publications
Cells must respond specifically and dynamically to mechanical cues from the extracellular
environment and dysregulation of extracellular force sensing leads to a variety of diseases …

Molecular nanomechanical mapping of histamine-induced smooth muscle cell contraction and shortening

MH Jo, BC Kim, K Sung, RA Panettieri Jr, SS An, J Liu… - ACS …, 2021 - ACS Publications
Mechanical response to external stimuli is a conserved feature of many cell types. For
example, neurotransmitters (eg, histamine) trigger calcium signals that induce actomyosin …

Quantifying molecular tension—classifications, interpretations and limitations of force sensors

A Yasunaga, Y Murad, ITS Li - Physical biology, 2019 - iopscience.iop.org
Molecular force sensors (MFSs) have grown to become an important tool to study the
mechanobiology of cells and tissues. They provide a minimally invasive means to optically …

Microscale interrogation of 3D tissue mechanics

J Zhang, NC Chada, CA Reinhart-King - Frontiers in bioengineering …, 2019 - frontiersin.org
Cells in vivo live in a complex microenvironment composed of the extracellular matrix (ECM)
and other cells. Growing evidence suggests that the mechanical interaction between the …

Epidermal growth factor receptor and integrins meet redox signaling through P66shc and Rac1

U Mushtaq, M Bashir, S Nabi, FA Khanday - Cytokine, 2021 - Elsevier
This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and
integrins in regulating Reactive oxygen species (ROS) production through different signaling …