C Zhu, Y Chen, LA Ju - Current opinion in chemical biology, 2019 - Elsevier
Mechanical forces are ubiquitous in a cell's internal structure and external environment. Mechanosensing is the process that the cell employs to sense its mechanical environment …
Although integrins are known to be mechanosensitive and to possess many subtypes that have distinct physiological roles, single molecule studies of force exertion have thus far …
Mechanical forces drive critical cellular processes that are reflected in mechanical phenotypes, or mechanotypes, of cells and their microenvironment. We present here …
Atomic force microscopy (AFM) provides a platform for high-resolution topographical imaging and the mechanical characterization of a wide range of samples, including live …
MH Jo, WT Cottle, T Ha - ACS Biomaterials Science & Engineering, 2018 - ACS Publications
Cells must respond specifically and dynamically to mechanical cues from the extracellular environment and dysregulation of extracellular force sensing leads to a variety of diseases …
Mechanical response to external stimuli is a conserved feature of many cell types. For example, neurotransmitters (eg, histamine) trigger calcium signals that induce actomyosin …
A Yasunaga, Y Murad, ITS Li - Physical biology, 2019 - iopscience.iop.org
Molecular force sensors (MFSs) have grown to become an important tool to study the mechanobiology of cells and tissues. They provide a minimally invasive means to optically …
Cells in vivo live in a complex microenvironment composed of the extracellular matrix (ECM) and other cells. Growing evidence suggests that the mechanical interaction between the …
This review examines the concerted role of Epidermal Growth Factor Receptor (EGFR) and integrins in regulating Reactive oxygen species (ROS) production through different signaling …