Cannabinoids and the expanded endocannabinoid system in neurological disorders

L Cristino, T Bisogno, V Di Marzo - Nature Reviews Neurology, 2020 - nature.com
Anecdotal evidence that cannabis preparations have medical benefits together with the
discovery of the psychotropic plant cannabinoid Δ9-tetrahydrocannabinol (THC) initiated …

Cannabinoid receptors and the endocannabinoid system: signaling and function in the central nervous system

S Zou, U Kumar - International journal of molecular sciences, 2018 - mdpi.com
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant
Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled …

Medical use of cannabinoids

AI Fraguas-Sánchez, AI Torres-Suárez - Drugs, 2018 - Springer
Cannabinoid receptors, endocannabinoids and the enzymes responsible for their
biosynthesis and degradation constitute the endocannabinoid system. In recent decades …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …

D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

The endocannabinoid system as an emerging target of pharmacotherapy

P Pacher, S Bátkai, G Kunos - Pharmacological reviews, 2006 - ASPET
The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

Pharmacology of cannabinoid CB1 and CB2 receptors

RG Pertwee - Pharmacology & therapeutics, 1997 - Elsevier
There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-
proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 …

Endocannabinoid system in neurodegenerative disorders

BS Basavarajappa, M Shivakumar… - Journal of …, 2017 - Wiley Online Library
Most neurodegenerative disorders (NDD s) are characterized by cognitive impairment and
other neurological defects. The definite cause of and pathways underlying the progression …

Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain

M Glass, RLM Faull, M Dragunow - Neuroscience, 1997 - Elsevier
The anatomical distribution and density of cannabinoid receptors in the human brain was
studied in one fetal (33weeks gestation), two neonatal (aged three to six months) and eight …

The endocannabinoid system and its therapeutic exploitation

VD Marzo, M Bifulco, LD Petrocellis - Nature reviews Drug discovery, 2004 - nature.com
The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …