Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …

Expansion microscopy (ExM) allows scalable imaging of preserved 3D biological specimens
with nanoscale resolution on fast diffraction-limited microscopes. Here, we explore the utility …

Iron homeostasis is tightly regulated by the membrane iron exporter ferroportin and its
regulatory peptide hormone hepcidin. The hepcidin/ferroportin axis is considered a …

Whole-mount immunofluorescence to detect activated Caspase 3 (Casp3 assay) is useful to
identify cells undergoing either intrinsic or extrinsic apoptosis in zebrafish embryos. The …

Congenital and progressive hearing impairment is a common distressing disease. The
progressive dominant hearing loss DFNA28 in human is associated with a frameshift …

斑马鱼作为重要的脊椎动物模式系统之一, 由于其多方面的优势, 在生命科学研究领域发挥着越
来越重要的作用. 目前, 斑马鱼已被广泛地用于发育生物学, 分子生物学, 细胞生物学, 遗传学 …

foxm1 is a master regulator of the cell cycle, contributing to cell proliferation. Recent data
have shown that this transcription factor also modulates gene networks associated with …

Abstract Cell Division Cycle 6 (Cdc6) is a component of pre-replicative complex (preRC)
forming on DNA replication origins in eukaryotes. Recessive mutations in ORC1, ORC4 …

Hepatic competence, specification, and liver bud expansion during development depend on
precise temporal modulation of the Wnt/β-catenin signaling. Also, loss-and gain-of-function …

Endothelial cells (ECs) play an important role in the pathogenesis of cardiovascular disease,
especially atherosclerosis (AS). The abnormal wall shear stress (WSS) which directly …