Venous thromboembolism (VTE) refers to deep vein thrombosis (DVT), whose consequence
may be a pulmonary embolism (PE). Thrombosis is associated with significant morbidity and …

Natural compounds are rich in pharmacological properties that are a hot topic in
pharmaceutical research. The quinoline ring plays important roles in many biological …

Purpose We aimed to investigate potential synergistic antiplatelet effects of Ginkgo biloba
extract (GBE50) in combination with aspirin using in vitro models. Methods Arachidonic acid …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Isosteviol is a tetracyclic diterpenoid obtained by hydrolysis of stevioside. Due to its unique
molecular skeleton and extensive pharmacological activities, isosteviol has attracted more …

Many populations suffer from thrombotic disorders such as stroke, myocardial infarction,
unstable angina and thromboembolic disease. Thrombus is one of the major threatening …

Steviol and isosteviol were prepared from the commercially available sweetener stevioside
and converted into lipophilic F16 hybrids. Their cytotoxicity was determined in SRB assays …

Acid hydrolysis of stevioside resulted in a 63% yield of isosteviol (1), which served as a
starting material for the preparation of numerous amides. These compounds were tested for …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

Novel oral anticoagulants are frequently used for the pharmacotherapy of thromboembolic
disorders but still have drawbacks and side effects. While numerous synthetic and …