Infections are a major threat to human reproductive health, and infections in pregnancy can
cause prematurity or stillbirth, or can be vertically transmitted to the fetus leading to …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

Preeclampsia is a major cause of maternal and perinatal morbidity and mortality. Early-onset
disease requiring preterm delivery is associated with a higher risk of complications in both …

Interventions to prevent pregnancy complications have been largely unsuccessful. We
suggest this is because the foundation for a healthy pregnancy is laid prior to the …

The term placental bed was coined to describe the maternal-fetal interface (ie, the area in
which the placenta attaches itself to the uterus). Appropriate vascularization of this area is of …

Maternal-fetal immune-tolerance occurs throughout the whole gestational trimester, thus a
mother can accept a genetically distinct fetus without immunological aggressive behavior …

Background The major challenge for obstetrics is the prediction and prevention of the great
obstetrical syndromes. We propose that defining obstetrical diseases by the combination of …

Gene–environment interactions begin at conception to influence maternal/placental/fetal
triads, neonates, and children with short-and long-term effects on brain development. Life …

Human parturition at term and preterm is an inflammatory process synchronously executed
by both fetomaternal tissues to transition them from a quiescent state t an active state of …

Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …