Loss of Malignancy of Super-Methotrexate-resistant Osteosarcoma Cells Is Associated With an Increase of Methylated Histone Marks H3K9me3 and H3K27me3

Y Aoki, Y Kubota, N Masaki, K Obara, Y Tome… - Anticancer …, 2024 - ar.iiarjournals.org
Background/Aim: Methotrexate (MTX) resistance in osteosarcoma results in a very poor
patient prognosis. We previously reported that super MTX-resistant osteosarcoma (143B …