Telomeres are essential for chromosomal integrity. Telomere shortening during cell division
restricts cellular proliferative capacity and leads to cellular senescence when critically …

A growing number of studies have evidenced non-telomeric functions of “telomerase”.
Almost all of them, however, investigated the non-canonical effects of the catalytic subunit …

Telomeres serve a critical function in cell replication and proliferation at every stage of the
cell cycle. Telomerase is a ribonucleoprotein, responsible for maintaining the telomere …

Cancer cells rely on the enzyme telomerase (EC 2.7. 7.49) to promote cellular immortality.
Telomerase inhibitors (ie, azidothymidine) can represent promising antitumor agents …

Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase
and plays important roles in human cancers. Aberrant expression of hTERT is closely …

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase
reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins …

Telomerase can overcome replicative senescence by elongation of telomeres but is also a
specific element in most cancer cells. It is expressed more vastly than any other tumor …

Small cell lung cancer (SCLC) has been a devastating actuality in clinic and the molecular
mechanisms underlying this disease remain unclear. The epigenetic alterations located in …

Regulatory T cells (Tregs) suppress the activity of effector T, B and NK lymphocytes and
sustain immunological tolerance, but the proliferative activity of suppressed cells remains …

Context Telomerase reverse transcriptase promoter (TERT-p) mutations, which upregulate
TERT expression, are strongly associated with tumor aggressiveness and worse prognosis …