Structural biology and regulation of protein import into the nucleus
Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …
their functions. Understanding how these nuclear proteins are transported through the …
Nuclear localization signals for four distinct karyopherin-β nuclear import systems
The Karyopherin-β family of proteins mediates nuclear transport of macromolecules. Nuclear
versus cytoplasmic localization of proteins is often suggested by the presence of NLSs …
versus cytoplasmic localization of proteins is often suggested by the presence of NLSs …
Recognition of the TDP-43 nuclear localization signal by importin α1/β
Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …
large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and …
[HTML][HTML] Transportin-1 and Transportin-2: protein nuclear import and beyond
Nearly 20 years after its identification as a new β-karyopherin mediating the nuclear import
of the RNA-binding protein hnRNP A1, Transportin-1 is still commonly overlooked in …
of the RNA-binding protein hnRNP A1, Transportin-1 is still commonly overlooked in …
Nonclassical nuclear localization signals mediate nuclear import of CIRBP
B Bourgeois, S Hutten, B Gottschalk… - Proceedings of the …, 2020 - National Acad Sciences
The specific interaction of importins with nuclear localization signals (NLSs) of cargo
proteins not only mediates nuclear import but also, prevents their aberrant phase separation …
proteins not only mediates nuclear import but also, prevents their aberrant phase separation …
Structural determinants of nuclear export signal orientation in binding to exportin CRM1
The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of
hundreds of proteins through recognition of their nuclear export signals (NESs), which are …
hundreds of proteins through recognition of their nuclear export signals (NESs), which are …
Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1
P Barraud, S Banerjee, WI Mohamed… - Proceedings of the …, 2014 - National Acad Sciences
The human RNA-editing enzyme adenosine deaminase acting on RNA (ADAR1) carries a
unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA …
unique nuclear localization signal (NLS) that overlaps one of its double-stranded RNA …
Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation
Heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) is a human ribonucleoprotein that
transports RNA to designated locations for translation via its ability to phase separate. Its …
transports RNA to designated locations for translation via its ability to phase separate. Its …
Karyopherin-β2 recognition of a PY-NLS variant that lacks the proline-tyrosine motif
Summary Karyopherin-β2 or Transportin-1 binds proline-tyrosine nuclear localization
signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall …
signals (PY-NLSs) in its cargos. PY-NLSs are described by structural disorder, overall …