Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

There is significant need to develop physiologically relevant models for investigating human
astrocytes in health and disease. Here, we present an approach for generating astrocyte …

The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …

The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …

Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Astrocytes are the most abundant cell type in the brain, where they perform a wide array of
functions, yet the nature of their cellular heterogeneity and how it oversees these diverse …

Astrocytes extend highly branched processes that form functionally isolated microdomains,
facilitating local homeostasis by redistributing ions, removing neurotransmitters, and …