The ubiquitous family of AP-1 dimeric transcription complexes is involved in virtually all
cellular and physiological functions. It is paramount for cells to reprogram gene expression …

As the second dimension to the genome, the epigenome contains key information specific to
every type of cells. Thousands of human epigenome maps have been produced in recent …

Genome-wide association studies (GWAS) have identified thousands of noncoding loci that
are associated with human diseases and complex traits, each of which could reveal insights …

Despite strong vetting for disease activity, only 10% of candidate new molecular entities in
early stage clinical trials are eventually approved. Analyzing historical pipeline data, Nelson …

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via
poorly understood mechanisms. We performed a trans-ancestry genome-wide association …

Genomic datasets are often interpreted in the context of large-scale reference databases.
One approach is to identify significantly overlapping gene sets, which works well for gene …

Methods for single-cell genome and transcriptome sequencing have contributed to our
understanding of cellular heterogeneity, whereas methods for single-cell epigenomics are …

The noncoding genome affects gene regulation and disease, yet we lack tools for rapid
identification and manipulation of noncoding elements. We developed a CRISPR screen …

Abstract Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative
human transcription factors. However, for most C2H2-ZF proteins it is unknown whether they …

To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …