Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Summary The cytokine interleukin-6 (IL6) and its downstream effector STAT3 constitute a
key oncogenic pathway, which has been thought to be functionally connected to estrogen …

Mutations in the pioneer transcription factor FOXA1 are a hallmark of estrogen receptor-
positive (ER+) breast cancers. Examining FOXA1 in∼ 5,000 breast cancer patients identifies …

FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal
organ precursors. Using a human stem cell model of pancreas differentiation, we here …

The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …

The cohesin complex is central to chromatin looping, but mechanisms by which these long-
range chromatin interactions are formed and persist remain unclear. We demonstrate that …

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds
to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the …

Abstract Treatment of prostate cancer confronts resistance to androgen receptor (AR)-
targeted therapies. AR-associated coregulators and chromatin proteins hold a great …