During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

The leading cause of death in developed countries is cardiovascular disease, where
coronary heart disease is the main cause of death. Myocardial reperfusion is the most …

Rationale: Timely restoration of coronary blood flow is the only way to salvage myocardium
from infarction, but reperfusion per se brings on additional injury. Such reperfusion injury …

Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and
transcription factor that plays important protective roles in the heart. The protection mediated …

Ischemia–reperfusion injury (IRI) is one of the biggest challenges for cardiovascular
researchers given the huge death toll caused by myocardial ischemic disease …

Acute myocardial infarction (AMI) is the leading cause of cardiovascular death and remains
the most common cause of heart failure. Reopening of the occluded artery, ie, reperfusion, is …