The dynamic behavior of epithelial cell sheets plays a central role during numerous
developmental processes. Genetic and imaging studies of epithelial morphogenesis in a …

With computation models playing an ever increasing role in the advancement of science, it is
important that researchers understand what it means to model something; recognize the …

This monograph presents a general mathematical theory for biological growth. It provides
both a conceptual and a technical foundation for the understanding and analysis of …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

We present a three-dimensional individual cell-based, biophysical model to study the effect
of normal and malfunctioning growth regulation and control on the spatial-temporal …

The dynamic behaviour of epithelial cell sheets plays a central role during development,
growth, disease and wound healing. These processes occur as a result of cell adhesion …

For nearly 150 years, it has been recognized that cell shape strongly influences the
orientation of the mitotic cleavage plane (eg, Hofmeister, 1863). However, we still …

The biomechanical modeling of growing tissues has recently become an area of intense
interest. In particular, the interplay between growth patterns and mechanical stress is of …

Voronoi tessellations have been used to model the geometric arrangement of cells in
morphogenetic or cancerous tissues, however, so far only with flat hyper-surfaces as cell …

Epithelia are sheets of tightly adherent cells that line both internal and external surfaces in a
vast array of metazoans. During development, an intrinsic consequence of coupling tight …