Recent advances in the synthesis of β-carboline alkaloids

T Szabó, B Volk, M Milen - Molecules, 2021 - mdpi.com
β-Carboline alkaloids are a remarkable family of natural and synthetic indole-containing
heterocyclic compounds and they are widely distributed in nature. Recently, these alkaloids …

Recent Advances on the Synthesis and Application of Tetrahydro‐β‐Carbolines

Y Du, A Semghouli, H Mei, L Kiss… - Advanced Synthesis & …, 2024 - Wiley Online Library
Tetrahydro‐β‐carbolines (THβCs) also known as tryptolines serve as important structural
elements in natural products and pharmaceutical compounds, and they are also utilized in …

Acceptorless Dehydrogenation of N-Heterocycles and Secondary Alcohols by Ru(II)-NNC Complexes Bearing a Pyrazoyl-indolyl-pyridine Ligand

Q Wang, H Chai, Z Yu - Organometallics, 2018 - ACS Publications
Ruthenium (II) hydride complexes bearing a pyrazolyl-(2-indol-1-yl)-pyridine ligand were
synthesized and structurally characterized by NMR analysis and X-ray single crystal …

Carboline regioisomers based on unified synthetic approaches

ASM Arshad, MN Mordi - Advanced Synthesis & Catalysis, 2023 - Wiley Online Library
Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and
bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ …

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors

M Sathish, B Kavitha, VL Nayak, Y Tangella… - European Journal of …, 2018 - Elsevier
A series of new podophyllotoxin linked β-carboline congeners have been synthesized by
coupling various substituted β-carboline acids with 4β-aminopodophyllotoxin. Evaluation of …

Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of …

S Srinath, R Abinaya, A Prasanth, M Mariappan… - Green chemistry, 2020 - pubs.rsc.org
Herein, a simple and efficient method for the oxidative dehydrogenation (ODH) of tetrahydro-
β-carbolines, indolines and tetrahydro-(iso) quinolines is described using a reusable …

One‐Pot Trimetallic Relay Catalysis: A Unified Approach for the Synthesis of β‐Carbolines and Other [c]‐Fused Pyridines

S Dhiman, UK Mishra, SSV Ramasastry - Angewandte Chemie, 2016 - Wiley Online Library
A divergent strategy is presented for the synthesis of 1, 3‐di‐and 1, 3, 4‐trisubstituted β‐
carbolines through an unprecedented one‐pot triple‐orthogonal‐metal relay catalysis, and …

Recent advances in benzocyclobutene chemistry

S Kotha, K Lahiri, Y Tangella - Asian Journal of Organic …, 2021 - Wiley Online Library
The benzocyclobutene (BCB) moiety is present in several bioactive natural products and
medicinally interesting molecules. BCB is also a valuable synthon for building a variety of …

Metal-free access to β-carbolines via single-electron transfer catalyzed by a triaryl carbenium ion pair

Z Zhang, J Gu, Y Lv, L Ji, X Liu, B Wu, F Liu… - Cell Reports Physical …, 2023 - cell.com
The β-carboline moiety exists in a wide range of drugs and natural products, but synthesis
often relies on noble metals and stochiometric oxidants. Here, we develop a metal-free …

Chromatography-Free Synthesis of β-Carboline 1-Hydrazides and an Investigation of the Mechanism of Their Bioactivity: The Discovery of β-Carbolines as …

T Sheng, C Yu, Y Wang, S Li, H Wu, Q Gu… - Journal of Medicinal …, 2023 - ACS Publications
Agrochemical science prioritizes the discovery and effective synthesis of innovative and
promising lead compounds. Herein, we developed an efficient column chromatography-free …