P2X receptors are nonselective cation channels gated by extracellular ATP. They represent
new therapeutic targets, and they form channels with a unique trimeric architecture. In 2009 …

ATP-gated P2X3 receptors are mostly expressed by nociceptive sensory neurons and
participate in transduction of pain signals. P2X3 receptors show a combination of fast …

P2X receptors are cation channels that sense extracellular ATP. Many therapeutic
candidates targeting P2X receptors have begun clinical trials or acquired approval for the …

P2X receptors are trimeric ATP-gated cation channels participating in diverse physiological
processes. How ATP binding triggers channel opening remains unclear. Here the gating …

Abstract P2X receptors, as ATP-gated non-selective trimeric ion channels, are permeable to
Na+, K+ and Ca 2+. Comparing with other ligand-gated ion channel families, P2X receptors …

Currently, adenosine 5′-triphosphate (ATP) is recognized as the extracellular messenger
that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y …

P2X receptors are a family of ligand gated ion channels found in a range of eukaryotic
species including humans but are not naturally present in the yeast Saccharomyces …

Background and Purpose It is assumed that ATP induces closure of the binding jaw of ligand‐
gated P 2 X receptors, which eventually results in the opening of the membrane channel and …

Abstract P2X receptors (P2X1–7) are non-selective cation channels involved in many
physiological activities such as synaptic transmission, immunological modulation, and …

The publication of the first crystal structures of the zebrafish P2X4 receptor in 2009 was a
pivotal moment; for the first time, researchers were able to interpret their experimental data …