Animal models have played a pivotal role in all stages of vaccine development. Their
predictive value for vaccine effectiveness depends on the pathogen, the robustness of the …

Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …

Over the past decade, a wealth of experimental evidence has accumulated supporting the
importance of Fc receptor (FcR) ligation in antibody‐mediated pathology and protection in …

Although IgA is the most abundantly produced immunoglobulin in humans, its role in
preventing HIV-1 acquisition, which occurs mostly via mucosal routes, remains unclear. In …

Recent immune correlates analysis from the RV144 vaccine trial has renewed interest in the
role of non-neutralizing antibodies in mediating protection from infection. While neutralizing …

Nonhuman primate models for the evaluation of HIV-1 preventi... : Current Opinion in HIV and
AIDS Nonhuman primate models for the evaluation of HIV-1 preventive vaccine strategies …

Introduction: Prevention of infection remains the ultimate goal for HIV vaccination, and there
is compelling evidence that antibodies directed to Envelope are necessary to block infection …

The macaque simian or simian/human immunodeficiency virus (SIV/SHIV) challenge model
has been widely used to inform and guide human vaccine trials. Substantial advances have …

Objective: Antibody-dependent enhancement (ADE) affects host-virus dynamics in
fundamentally different ways: i) enhancement of initial virus acquisition, and/or ii) increased …

Staphylococcus aureus (S. aureus) is an opportunistic bacterial pathogen responsible for a
diverse spectrum of human diseases, resulting in considerable yearly mortality rates. Due to …