Young-onset colorectal cancer

MCW Spaander, AG Zauber, S Syngal… - Nature reviews Disease …, 2023 - nature.com
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Gut microbiome and its role in colorectal cancer

M Rebersek - BMC cancer, 2021 - Springer
Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and
the gut microbiome plays an important role in its development. The microbiome is involved …

Growth factors, PI3K/AKT/mTOR and MAPK signaling pathways in colorectal cancer pathogenesis: where are we now?

C Stefani, D Miricescu, II Stanescu-Spinu… - International journal of …, 2021 - mdpi.com
Colorectal cancer (CRC) is a predominant malignancy worldwide, being the fourth most
common cause of mortality and morbidity. The CRC incidence in adolescents, young adults …

Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis

DE O'Sullivan, RL Sutherland, S Town, K Chow… - Clinical …, 2022 - Elsevier
Background & Aims Despite the widespread increase in the incidence of early-onset
colorectal cancer (EoCRC), the reasons for this increase remain unclear. The objective of …

An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer

AN Burnett-Hartman, JK Lee, J Demb, S Gupta - Gastroenterology, 2021 - Elsevier
Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those
who are younger than 50 years have been well established. These trends have spurred …

Rising incidence of early-onset colorectal cancer—A call to action

N Akimoto, T Ugai, R Zhong, T Hamada… - Nature reviews Clinical …, 2021 - nature.com
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals< 50 years
of age, has been increasing worldwide and particularly in high-income countries. The …

Early-onset colorectal cancer: initial clues and current views

LJ Hofseth, JR Hebert, A Chanda, H Chen… - Nature reviews …, 2020 - nature.com
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …

Changes in colorectal cancer incidence in seven high-income countries: a population-based study

M Araghi, I Soerjomataram, A Bardot… - The lancet …, 2019 - thelancet.com
Background The overall incidence of colorectal cancer is decreasing in many high-income
countries, yet analyses in the USA and other high-income countries such as Australia …

ω-3 and ω-6 polyunsaturated fatty acids, obesity and cancer

S D'Angelo, ML Motti, R Meccariello - Nutrients, 2020 - mdpi.com
Recently, nutraceutical bioactive compounds in foods have been discovered for their
potential health benefits regarding the prevention of chronic disorders, such as cancer, and …

Sexual dimorphism in colon cancer

M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …