Pathobiology of pulmonary hypertension
M Rabinovitch - Annu. Rev. Pathol. Mech. Dis., 2007 - annualreviews.org
A variety of conditions can lead to the development of pulmonary arterial hypertension
(PAH). Current treatments can improve symptoms and reduce the severity of the …
(PAH). Current treatments can improve symptoms and reduce the severity of the …
Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases
EA Ko, WS Park, AL Firth, N Kim, JXJ Yuan… - Progress in biophysics …, 2010 - Elsevier
In this review, the pathological alteration and clinical relevance of voltage-gated K+ (Kv)
channels and their specific regulation by protein kinase-dependent signaling in vascular …
channels and their specific regulation by protein kinase-dependent signaling in vascular …
Dynamin-related protein 1–mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in …
Rationale: Pulmonary arterial hypertension (PAH) is a lethal syndrome characterized by
pulmonary vascular obstruction caused, in part, by pulmonary artery smooth muscle cell …
pulmonary vascular obstruction caused, in part, by pulmonary artery smooth muscle cell …
miR‐1 is increased in pulmonary hypertension and downregulates Kv1. 5 channels in rat pulmonary arteries
G Mondejar‐Parreño, M Callejo… - The Journal of …, 2019 - Wiley Online Library
Key points The expression of miR‐1 is increased in lungs from the Hyp/Su5416 PAH rat
model. Pulmonary artery smooth muscle cells from this animal model are more depolarized …
model. Pulmonary artery smooth muscle cells from this animal model are more depolarized …
[HTML][HTML] hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension
X Jin, Y Xu, M Guo, Y Sun, J Ding, L Li, X Zheng… - … Therapy-Nucleic Acids, 2021 - cell.com
In this study, we explored the circular RNA (circRNA) profile in pulmonary arterial
hypertension (PAH) patients caused by chronic obstructive pulmonary disease (COPD) and …
hypertension (PAH) patients caused by chronic obstructive pulmonary disease (COPD) and …
[HTML][HTML] ACE2: A novel therapeutic target for cardiovascular diseases
S Der Sarkissian, MJ Huentelman, J Stewart… - Progress in biophysics …, 2006 - Elsevier
Hypertension afflicts over 65 million Americans and poses an increased risk for
cardiovascular morbidity such as stroke, myocardial infarction and end-stage renal disease …
cardiovascular morbidity such as stroke, myocardial infarction and end-stage renal disease …
Rodent models of group 1 pulmonary hypertension
Abstract World Health Organization category 1 pulmonary hypertension (PH) is a
heterogeneous syndrome in which PH originates in the small pulmonary arteries and is …
heterogeneous syndrome in which PH originates in the small pulmonary arteries and is …
Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is an orphan disease of the cardiopulmonary unit
that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy …
that reflects an obstructive pulmonary vasculopathy and presents with hypertrophy …
Fhl-1, a new key protein in pulmonary hypertension
G Kwapiszewska, M Wygrecka, LM Marsh, S Schmitt… - Circulation, 2008 - Am Heart Assoc
Background—Pulmonary hypertension (PH) is a severe disease with a poor prognosis.
Different forms of PH are characterized by pronounced vascular remodeling, resulting in …
Different forms of PH are characterized by pronounced vascular remodeling, resulting in …
Important Functions and Molecular Mechanisms of Mitochondrial Redox Signaling in Pulmonary Hypertension
Mitochondria are important organelles that act as a primary site to produce reactive oxygen
species (ROS). Additionally, mitochondria play a pivotal role in the regulation of Ca2+ …
species (ROS). Additionally, mitochondria play a pivotal role in the regulation of Ca2+ …