As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …

Two-thirds of human hormones and one-third of clinical drugs activate~ 350 G-protein-
coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of …

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …

Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple
diseases; however, there remains substantial interest in the development of orally delivered …

Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

INTRODUCTION G protein–coupled receptors (GPCRs) are key regulators of information
transmission between cells and organs. Among these, class B1 GPCRs are activated by …

Class B1 G protein-coupled receptors (GPCRs) play important roles in human physiology
and disease pathology. Using cryo-electron microscopy (cryo-EM) and X-ray …