Aptamer in bioanalytical applications

AB Iliuk, L Hu, WA Tao - Analytical chemistry, 2011 - ACS Publications
(2009À2010), thefield of aptamer research has continuously generated lots of interest in the
scientific community. Aptamers, first reported by three groups independently in 1990, 1À3 …

Alternative affinity tools: more attractive than antibodies?

VJB Ruigrok, M Levisson, MHM Eppink… - Biochemical …, 2011 - portlandpress.com
Antibodies are the most successful affinity tools used today, in both fundamental and applied
research (diagnostics, purification and therapeutics). Nonetheless, antibodies do have their …

Aptamers: problems, solutions and prospects

AV Lakhin, VZ Tarantul, LV Gening - Acta Naturae (англоязычная …, 2013 - cyberleninka.ru
Aptamers are short single-stranded oligonucleotides that are capable of binding various
molecules with high affinity and specificity. When the technology of aptamer selection was …

Engineering aptamer with enhanced affinity by triple helix-based terminal fixation

L Zhao, X Qi, X Yan, Y Huang, X Liang… - Journal of the …, 2019 - ACS Publications
The affinity of aptamers relies on their adaptive folding, but the excessive flexibility of the
aptamer backbone usually hampers the folding process. Thus, there is an urgent need to …

Single-stranded DNA (ssDNA) production in DNA aptamer generation

C Marimuthu, TH Tang, J Tominaga, SC Tan… - Analyst, 2012 - pubs.rsc.org
The discovery that synthetic short chain nucleic acids are capable of selective binding to
biological targets has made them to be widely used as molecular recognition elements …

Aptamers: an emerging navigation tool of therapeutic agents for targeted cancer therapy

C Yang, Y Jiang, SH Hao, XY Yan… - Journal of materials …, 2022 - pubs.rsc.org
Chemotherapeutic agents have been used for the treatment of numerous cancers, but due to
poor selectivity and severe systemic side effects, their clinical application is limited. Single …

Preparation of a highly sensitive electrochemical aptasensor for measuring epirubicin based on a gold electrode boosted with carbon nano-onions and MB

E Sohouli, M Ghalkhani, T Zargar, F Ahmadi - Biosensors, 2022 - mdpi.com
Epirubicin is prescribed as an essential drug for treating breast, prostate, uterine, and
gastrointestinal cancers. It has many side effects, such as heart failure, mouth inflammation …

Capillary electrophoresis applied to DNA: determining and harnessing sequence and structure to advance bioanalyses (2009–2014)

BC Durney, CL Crihfield, LA Holland - Analytical and bioanalytical …, 2015 - Springer
This review of capillary electrophoresis methods for DNA analyses covers critical advances
from 2009 to 2014, referencing 184 citations. Separation mechanisms based on free-zone …

DNA Aptamer beacon probe (ABP) for monitoring of adenosine triphosphate level in SW480 cancer cells treated with glycolysis inhibitor 2-deoxyglucose

K Ratajczak, M Stobiecka - International Journal of Molecular Sciences, 2023 - mdpi.com
Early cancer screening enables timely detection of carcinogenesis, and aids in prompt
clinical intervention. Herein, we report on the development of a simple, sensitive, and rapid …

Development of bacteriostatic DNA aptamers for salmonella

OS Kolovskaya, AG Savitskaya, TN Zamay… - Journal of medicinal …, 2013 - ACS Publications
Salmonella is one of the most dangerous and common food-borne pathogens. The overuse
of antibiotics for disease prevention has led to the development of multidrug resistant …