Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …

Epithelial–mesenchymal transition (EMT) programs operate within carcinoma cells, where
they generate phenotypes associated with malignant progression. In their various …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Stemness combines the ability of a cell to perpetuate its lineage, to give rise to differentiated
cells, and to interact with its environment to maintain a balance between quiescence …

Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb repressive
complex 2 (PRC2), has attracted broad research attention in the past few years because of …

Despite possessing limited protein-coding potential, long non-coding RNAs (lncRNAs) have
been implicated in a myriad of pathologic conditions. Most well documented in cancer, one …

Tumor metastasis and recurrence is one of the biggest problems in curing cancers. Due to
the difficulty in complete removal of the primary tumor in traditional surgeries and the poor …